Porter Stoddard (Warren Beatty) is a well-known New York architect with a supremely successful life. But after a series of comic missteps, he finds his devoted wife Ellie (Diane Keaton) is suspicious of his whereabouts and his soon-to-be adult children (Josh Harnett and Tricia Vessey) don't seem to need him anymore. Meanwhile, Mona (Goldie Hawn), Porter's childhood friend, has just found out her husband Griffin (Gary Shandling) is having an affair, just as Griffin, his best friend, is on the verge of leavinghis old life behind. Shocked that Mona has now filed for divorce, Porter tries to pull his own life together before it's too late. But instead, he only winds up making matters worse. As Mona and Ellie ponder the foolish choices men make, porter slips into a series of bizarre comic adventures. Soon he and Mona grow dangerously close as life with Ellie begins to fall apart. Not knowing what to do, he does what any other self-respecting American male would do - he escapes with his best friend to search for some meaning to their quietly disintegrating lives. Along the way they meet up with Eugenie (Andie MacDowell), a jet-setting heiress, and her daffy eccentric parents (Charlton Heston and Marian Seldes); Auburn (Jenna Elfman), the free-spirited owner of a bait and tackle shop; and Alex (Nastassja Kinski), a beautiful cellist who may or may not be carrying Porter's Child. But just as it becomes evident neither man is the person he thought he was, each decide to use the one final weapon they have left-honesty. Suddenly the lives of both couples come together in a raucous denouement as they try to reclaim the part of themselves they seemed destined to forget.