'Saints-Martyrs-des-Damnes' follows tabloid reporter Flavien Juste as he investigates strange disappearances in a remote, rundown village. Sent there by his surrogate father, the paper's editor, Flavien thinks it's just another routine assignment. But, then, Flavien's photographer pal Armand suddenly vanishes on their very first night in town. And, everyone in town seems disturbed by the sight of Flavien. Dreams, reality and hallucinations begin to intermingle, and before long he can't even trust his own eyes. Flavien is eventually forced to confront his own mysterious origins as well as accept some newfound responsibilities.