A Portland couple have two children with Pompe disease, a genetic disease that kills children before their tenth birthday. The father John (Brendan Frasier), who's in advertising, contacts Robert Stonehill (Harrison Ford), a researcher who has a theory on an enzyme treatment. He is underfunded to pursue his research, and has an abrasive personality that drives away his colleagues and funders. John and his wife Aileen (Keri Russell) raise money to get Stonehill going, then John takes on the task full time, working with venture capitalists and a rival team of researchers. Time is passing, Stonehill's antics get in the way, and greed may dash John's hopes. Will the researchers succeed in time to save the Crowley's children?