Thirty centuries ago on the planet Drakulon a cult led by Vlad kills the Council and escapes to earth to become the bloodsuckers known as vampires. Ella, daughter of the slain High Elder, pursues the cult with vengeance in her heart. Shipwrecked for centuries on Mars, she eventually gets to earth as stowaway on a manned expedition. On present day earth Adam, a descendant of the Van Helsings, works for PURGE, a paramilitary group dedicated to hunting vampires. Ella is now known as Vampirella, and must form an uneasy alliance with Adam in order to locate and deal with their common enemy, Vlad.