Jimmy Livingston is happy enough, and has all the same experiences of other boys and girls growing up... except he's lived his whole life in a hermetically sealed bubble. However, when Jimmy realizes that he's in love with Chloe, the girl next door, he has no choice but to build a mobile "bubble suit" and venture out of his bedroom. He sets off across the country to Niagara Falls, to stop Chloe's wedding--which is only days away--in time to confess his love to her. As Jimmy sees the world for the first time, he encounters a motley crew of people. Along the way, he crosses paths with freaks, bikers, rock stars, and a cult--all the while, racing against the clock and his parents who are determined to bring Jimmy back to the safety of his "bubble room."